ELISA Substrates and Reagents
Bioss JNK - Thr-183/Tyr-185 Phospho
JNK (Thr-183/Tyr-185) Primary Antibody Unconjugated Host Species Mouse Target Species Human Mouse Rat Clonality Monoclonal Applications WB M268Concentration Size 100 ul Storage Buffer PBS 1 mg/ml BSA 0 05% NaN3 and 50% glycerol
ABclonal Technology Phospho-Akt-S473 Rabbit mAb
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts AKT1 and the related AKT2 are activated by platelet-derived growth factor The activation is rapid and specific and it is abrogated by mutations in the pleckstrin homology domain of AKT1 It was shown that the activation occurs through phosphatidylinositol 3-kinase In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine threonine kinase AKT1 which then phosphorylates and inactivates components of the apoptotic machinery Mutations in this gene have been associated with the Proteus syndrome Multiple alternatively spliced transcript variants have been found for this gene [provided by RefSeq Jul 2011]
ABclonal Technology Phospho-NF-B2-S866/S870
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner The p100 full-length protein is co-translationally processed into a p52 active form Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas some of which may result in the formation of fusion proteins There is a pseudogene for this gene on chromosome 18 Alternative splicing results in multiple transcript variants
Bioss Osteopontin - N-terminal regio
Osteopontin (N-terminal region) Primary Antibody Unconjugated Host Species Mouse Target Species Human Mouse Rat Clonality Monoclonal Applications WB M574Concentration Size 100 ul Storage Buffer PBS 1 mg/ml BSA 0 05% NaN3 and 50% glycerol
ABclonal Technology Phospho-ErbB3/HER3-Y1328 Rabbit pAb
This gene encodes a member of the epidermal growth factor receptor (EGFR) family, a membrane-bound protein that binds neuregulin but lacks an active kinase domain. It does not directly convey signals but forms heterodimers with other EGFR family members that have kinase activity. Heterodimerization activates pathways leading to cell proliferation or differentiation. Amplification or overexpression of this gene is found in cancers such as prostate, bladder, and breast tumors. Alternative splicing produces isoforms, including one that lacks the intermembrane region and is secreted to modulate the membrane-bound form’s activity. Other splice variants have been reported but are not fully characterized.
ABclonal Technology ErbB3/HER3 Rabbit pAb
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. It has a neuregulin binding domain but lacks an active kinase domain, so it binds the ligand without transmitting signals via protein phosphorylation. It forms heterodimers with other EGFR family members that have kinase activity, activating pathways for cell proliferation or differentiation. Amplification or overexpression of this gene is linked to various cancers, including prostate, bladder, and breast tumors. Alternative splice variants encoding different isoforms have been identified, including one isoform that lacks the intermembrane region and is secreted to modulate the membrane-bound form’s activity. Other splice variants have been reported but are not fully characterized.
ABclonal Technology Phospho-Tyk2-Y1054/1055 Rabbit pAb
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
ABclonal Technology Phospho-PEA15-S104 Rabbit pAb
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants.
Genscript Corporation CEACAM-8/CD66bBiotin His
Eosinophils and their products are likely important in the pathophysiology of allergic diseases such as bronchial asthma and in host immunity to parasitic organisms CD66b (CEACAM8 CGM6 NCA-95) is a single chain GPI-anchored highly glycosylated protein belonging to the carcinoembryonic Ag supergene family CD66b is an activation marker for human granulocytes
Meso Scale Discovery RPLEX HUM ERK1/2 total ASYQP
The R-PLEX Human ERK1/2 Total Assay Kit from Meso Scale Discovery is used to quantitatively measure total ERK1/2 levels in cell lysates The assay uses an electrochemiluminescent detection method and provides high sensitivity broad dynamic range and requires low sample input The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer blocker solutions calibrator and positive control lysate The assay can detect total ERK1/2 levels between 50 pg/mL to 50 000 pg/mL It is compatible with lysates from adherent and suspension cultured cells The kit provides all necessary reagents for the immunoassay
Meso Scale Discovery R-PLEX Human HSP27/HspB1 ASYQP
The R-PLEX Human HSP27 (HSPB1) Assay is an ELISA kit for the quantitative measurement of HSP27 in human serum plasma cell culture supernatants cell and tissue lysates and other biological fluids It uses a quantitative sandwich immunoassay technique and comes with a 96-well strip plate that is pre-coated with antibodies specific for HSP27 The detection range for this assay is 15 6-1000 pg/mL with a sensitivity of 5 pg/mL This assay kit provides materials to run up to 40 samples in duplicate and takes around 3 hours to complete Overall the R-PLEX Human HSP27 Assay provides a sensitive high-throughput method for quantifying HSP27 levels in various human sample types
Sino Biological Recombinant Human BAFF/BLyS/TNFSF13B Protein (ECD), Endotoxin-Free
A DNA sequence encoding the soluble form of human BAFF (Q9Y275-1) (Ala 134-Leu 285) was expressed and purified.
ABclonal Technology Phospho-NF-kB p65/RelA-T435 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
![ABclonal Technology [KO Validated] ErbB3/HER3 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000135007.jpg-250.jpg)
ABclonal Technology [KO Validated] ErbB3/HER3 Rabbit pAb
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The protein has a neuregulin-binding domain but lacks an active kinase domain, so it can bind the ligand but cannot transmit the signal. However, it forms heterodimers with other EGFR family members with kinase activity, activating pathways that lead to cell proliferation or differentiation. Gene amplification or overexpression of this protein has been observed in cancers like prostate, bladder, and breast tumors. Alternate splice variants have been characterized, including one isoform that lacks the intermembrane region and is secreted outside the cell, where it modulates the activity of the membrane-bound form. Other splice variants have been reported but are not fully characterized.